Class of 2021

Principal Investigator
Prof. Dr. Andreas Diefenbach

ILC3 as regulators of intestinal organ hypertrophy in response to increased metabolic demands during pregnancy and lactation

We study development and function of the innate immune system, in particular of innate lymphoid cells (ILC). A current focus is to obtain a molecular understanding of how the innate immune system, by integrating environmental …

Principal Investigator
Prof. Dr. Kamran Ghoreschi

Tfh and Th17 cells as markers for the risk for pemphigoid diseases in aging healthy skin

Our laboratory focuses on the immunological and molecular pathomechanisms of the skin with the aim to identify approaches for personalized and preventive medicine. One group of our translational research interests are chronic …

Principal Investigator
Prof. Dr. Anja Hauser

Mechanosensing of intestinal macrophages

Our lab is interested in analyzing immune cells in the tissue context, using state-of-the art, functional intravital microscopy and histocytometry approaches. In addition to reacting to stimuli from hematopoietic and …

Principal Investigator
Prof. Dr. Marcus A. Mall
Dr. Markus Bardua

Membrane-bound neutrophil elastase as a potential biomarker for early detection of chronic inflammatory diseases

Biomarkers play a central role in detecting chronic inflammatory diseases before irreversible tissue damage occurs. These measurable, ideally disease-specific, indicators can be detected in the organism even before the onset …

Principal Investigator
Dr. Christoph Klose

Dissecting tissue-homeostatic functions of group 2 innate lymphoid cells

Type 2 immune responses promote tissue homeostasis as well as tissue remodeling and protect against infections with macroparasites but can become detrimental when triggered against non-infectious environmental stimuli

Principal Investigator
Prof. Dr. Felix Knauf,
PD Dr. Martin Reichel,
Dr. Nicola Wilck

The adaptation of the intestinal epithelium to an oxalate-containing diet

Our laboratory focuses on the mechanisms involved in maintaining oxalate homeostasis. Oxalate is a component of various foods, found in different vegetables, nuts, but also in tea and coffee. High urinary oxalate …

Principal Investigator
Prof. Dr. Leif Erik Sander

From infection to fibrosis – defining common immune determinants of disease and resolution

Resilience to infections is equally defined by the host’s ability to clear the infecting pathogen and to resolve and mitigate secondary injury, and thus to restore and maintain tissue homeostasis. These physiological …

Principal Investigator
Prof. Dr. Frank Tacke,
Dr. Linda Hammerich

Characterization of the immune microenvironment in gastrointestinal tumors using single cell techniques

Our lab studies the role of immune cells and inflammatory processes in the liver. Infiltration and activation of immune cells play an important role during the development of acute and chronic liver diseases, but the exact …

Principal Investigator
Prof. Dr. Antigoni Triantafyllopoulou

Immunoregulatory role of macrophages and microglia in CNS lupus

Our research aims to understand the role of tissue-resident cells of the innate immune system in the prevention of chronic inflammatory diseases such as systemic lupus erythematosus and inflammatory bowel disease. Our goal is …

Principal Investigator
Valentin Vecera

Influence of CKD-associated microbiome changes on the immune system and cardiovascular risk

Our laboratory investigates the interaction of dietary factors with the gut microbiota and the host, especially with the host’s immune system, in the context of cardiovascular and renal disease. Arterial hypertension and …