Crosstalk between intestinal macrophages and innate lymphoid cells
Scientific interest within the context of the graduate college:
Our research aims to understand the role of tissue-resident cells of the innate immune system in the prevention of chronic inflammatory diseases such as systemic lupus erythematosus and inflammatory bowel disease. Our goal is to identify mechanisms that may inhibit the transition from homeostasis to chronic inflammatory disease and to determine the role of tissue-resident cells of the innate immune system in this process. Understanding such mechanisms may allow to answer the question of why some patients are susceptible to chronic autoimmune-related inflammatory diseases and others are not, and how to improve/achieve resistance to chronic inflammatory diseases.
Project description:
The overarching goal of our research is to better understand the role of tissue-derived cells of the innate immune system in the prevention of chronic inflammatory diseases. Our specific objective is to identify mechanisms that can inhibit the transition from homeostasis to chronic inflammatory diseases. A comprehensive understanding of these mechanisms could help to clarify why certain patients are more susceptible to chronic inflammatory diseases than others. Furthermore, we want to understand how resistance to chronic inflammatory diseases can be improved or achieved.